Don’t follow the beaten path that every traveller takes, just because you feel like you should. What interests you? What do you want to see and learn about? One of the first stops on my trip was Chernobyl — not exactly a popular tourist destination. I didn’t know anybody who had been there, but it sounded fascinating to me. This is your trip: go where excites you, not where you feel you should go.

I love your suggestions, but I want to strongly caution against #73. I’m a retired chemist from the pharmaceutical industry, and I can tell you that prescription drugs sold in blister packs are that way for a very good reason; not simply because pharma likes higher manufacturing and shipping costs. They are that way because the drugs require them for stability, generally because of moisture, UV, or even atmospheric oxygen. Best case, they lose potency. Worst case, they create toxic degradation products. I personally take drugs out of the box, but not the blisters, and store them where they won’t get a lot of light and heat.
Though Amtrak is the largest train service in the state, it’s not the only way to roll. In Northern California, Caltrain has regular service between San Francisco and San Jose. In Southern California, Metrolink offers service on seven regional lines that connect L.A., Ventura County, Antelope Valley, San Bernardino, Riverside, Orange County, and the Inland Empire. Trains dedicated to certain themes and in specific locales, such as the Napa Valley Wine Train, also provide a unique way to see some of California’s premier destinations.

If you’re travelling in a group or a pair, talk to your travel buddy about what you’re both packing so you don’t double up. For example, girls, if you’re travelling with a mate and can’t live without your straighteners, maybe one of you can bring a hair drier and one of you can bring the straighteners (although do consider going au-natural – it’s liberating!)
If you’re suffering from food poisoning, it’s best to let it run its course rather than clogging yourself up with Imodium, but there are some situations where it just isn’t possible to do so. I’m talking flights, long bus journeys, booked tours, and anything that requires you to leave the bathroom. A large supply of Imodium is something I always have in my backpack for these emergencies.
Are you lured by clever commercials that promise 4 star accommodations for the cost of a 1 star? Consider this: Booking directly with a hotel or chain has far more value than a quick fix. Here's why: Generally, hotels will not take your money until you show up. If you no-show or cancel, they will take only 1 night's cost, no hassle changes can be made to your reservation, and their website always has to have a better deal than what you can get from those 3rd party 'tempters'. Choose wisely!
Make the most of your layover in Iceland by booking one of Icelandair's tours, including a transfer to the Blue Lagoon between flights. See Dubai without having to pay for a visa with Emirates' stopover offer, which includes a free visa for a one-night stay. Get to the Eiffel Tower, even if you only have seven hours at Paris' Charles de Gaulle Airport, by booking the Paris Transit Tour from Aeroports de Paris.
It also helps to know which items are, according to the TSA, considered liquids or gels and thereby subject to the 3-1-1 rule. This isn't as simple as it sounds. Foods such as peanut butter, pudding, mashed potatoes, and icing are classified as gels. Mascara, lip gloss, and aerosol items are also classified as liquids or gels. But keep in mind that liquid prescription medication is exempt. (Read more on that on The TSA Blog.) See a more complete list of liquids and gels that are not permitted in carry-on luggage in quantities greater than 3.4 ounces here. 
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